![]() Bioanalysis of antibody–drug conjugates: American Association of Pharmaceutical Scientists Antibody–Drug Conjugate Working Group position paper. Discusses an ELISA method for antibody–drug conjugates (ADCs) and their catabolites.Sensitive ELISA method for the measurement of catabolites of antibody–drug conjugates (ADCs) in target cancer cells. 2018 white paper on recent issues in bioanalysis: focus on immunogenicity assays by hybrid LBA/LCMS and regulatory feedback (part 2 – PK, PD & ADA assays by hybrid LBA/LCMS & regulatory agencies' inputs on bioanalysis, biomarkers and immunogenicity). Perspectives on potentiating immunocapture LC-MS for the bioanalysis of biotherapeutics and biomarkers. Sugimoto H, Wei D, Dong L, Ghosh D, Chen S, Qian MG. Antibody–drug conjugate bioanalysis using LB-LC-MS/MS hybrid assays: strategies, methodology and correlation to ligand-binding assays. Multiplex LC-MS/MS assays for clinical bioanalysis of MEDI4276, an antibody–drug conjugate of tubulysin analogue attached via cleavable linker to a biparatopic humanized antibody against HER-2. Anti-extra domain B splice variant of fibronectin antibody–drug conjugate eliminates tumors with enhanced efficacy when combined with checkpoint blockade. Hooper AT, Marquette K, Chang C-PB et al. Expression of fibronectin isoforms in human breast tissue: production of extra domain A+/extra domain B+ by cancer cells and extra domain A+ by stromal cells. Matsumoto E, Yoshida T, Kawarada Y, Sakakura T. Magnetic resonance molecular imaging of extradomain B fibronectin enables detection of pancreatic ductal adenocarcinoma metastasis. ED-B fibronectin in non-small cell lung carcinoma. Khan ZA, Caurtero J, Barbin YP, Chan BM, Uniyal S, Chakrabarti S. Extra-domain B of fibronectin as an alternative target for drug delivery and a cancer diagnostic and prognostic biomarker for malignant glioma. A novel human fibronectin cryptic sequence unmasked by the insertion of the angiogenesis-associated extra type III domain B. Evaluation of EDB fibronectin in plasma, patient-derived xenograft formalin-fixed paraffin-embedded and fresh frozen tumor tissues using immunoaffinity LC-MS/MS. ![]() ![]() Li F, Hooper AT, Golas J, Chang C-PB, Neubert H, King L. ED-B fibronectin as a target for antibody-based cancer treatments. Expression of the oncofetal ED-B-containing fibronectin isoform in hematologic tumors enables ED-B-targeted 131I-L19SIP radioimmunotherapy in Hodgkin lymphoma patients. Papers of special note have been highlighted as: ![]()
0 Comments
Leave a Reply. |